Reactivation yeLatent HIV-1 Infection nePeriodontopathic Bacterium

Maseru ane hutachiwana ane HIV-1 proviral DNA genome inonyanya kusanganiswa muheterochromatin, zvichibvumira kuenderera mberi kwemaproviruses akanyarara.Hypoacetylation ye histone proteins ne histone deacetylases (HDAC) inobatanidzwa mukuchengetedza HIV-1 latency nekudzvinyirira hutachiona hwehutachiona.Pamusoro pezvo, zvirwere zve periodontal, zvinokonzerwa nepolymicrobial subgingival bacteria kusanganisira Porphyromonas gingivalis, ndezvimwe zvezvirwere zvatekeshera muvanhu.Pano tinoratidza zvinokonzerwa neP. gingivalis pakudzokorora kweHIV-1.Chiitiko ichi chinogona kuverengerwa kune bhakitiriya tsika inodarika asi kwete kune zvimwe zvinhu zvehutachiona senge fimbriae kana LPS.Takaona kuti chiitiko ichi cheHIV-1-inducing chakadzoserwa muchikamu chepasi chemolecular mass (<3 kDa) chikamu chetsika inoshamisa.Takaratidzawo kuti P. gingivalis inogadzira huwandu hwakawanda hwebutyric acid, ichiita sechinhu chine simba inhibitor yeHDACs uye ichikonzera histone acetylation.Chromatin immunoprecipitation assays yakaratidza kuti iyo corepressor complex ine HDAC1 uye AP-4 yakaparadzaniswa kubva kune HIV-1 refu terminal inodzokorora kusimudzira pakusimudzira nehutachiona tsika supernatant pamwe nekubatanidzwa kweacetylated histone uye RNA polymerase II.Saka takaona kuti P. gingivalis inogona kukonzera HIV-1 reactivation kuburikidza ne chromatin modification uye kuti butyric acid, imwe yemabhakitiriya metabolites, inokonzera izvi.Mhedzisiro iyi inoratidza kuti chirwere cheperiodontal chinogona kuita sengozi yekudzoreredzwa kweHIV-1 muvanhu vane hutachiona uye zvinogona kubatsira mukupararira kwehutachiona.